低出生体重与增加的同情活动有关:依赖遗传因素
Richard G IJzerman1, Coen D A Stehouwer, Eco J de Geus
1Department of Internal Medicine and Institute for Cardiovascular Research , VU University Medical Center, Amsterdam, The Netherlands.
Circulation
|July 16, 2003
概括
低出生体重与成年期高血压有关,通过交感神经系统活动的增加来调解. 这种关联似乎受到遗传因素的影响,特别是在双胞胎双胞胎中.
科学领域:
- 心血管生理学心血管生理学
- 健康和疾病的发育起源 (DOHaD)
- 双胞胎研究 双胞胎研究
背景情况:
- 低出生体重是生命后期高血压的潜在危险因素.
- 自主神经系统活动 (交感和副交感) 可能会调解这种关联.
- 遗传因素也可能在出生体重与血压关系中发挥作用.
研究的目的:
- 调查出生体重与交感和副交感活动指标之间的关联.
- 为了检查青少年双胞胎出生体重和血压之间的关系.
- 探索遗传因素在出生体重-自主活动-血压路径中的作用.
主要方法:
- 研究了53个双胞胎双胞胎和61个单双胞胎的青少年双胞胎.
- 测量心脏预排期 (交感指标) 和呼吸道鼻节律失常 (副交感指标).
- 在休息和压力任务 (反应时间,心理算术) 中利用心电图和阻抗心脏图.
主要成果:
- 较低的出生体重与更短的休息和压力任务前排气期相关.
- 在对内分析显示,双胞胎双胞胎的出生体重差异与双胞胎但非单胞胎双胞胎的前排期差异有关.
- 较短的预喷射期解释了出生体重与血压相关性的很大一部分 (63-84%).
结论:
- 低出生体重与同情神经系统活动的增加有关.
- 增加的同情活动部分解释了低出生体重和高血压之间的联系.
- 遗传因素影响着出生体重和同情活动之间的关系.
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