相关实验视频
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Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
Published on: April 9, 2019
前额头肌叶片第二阶段chordes tendineae对左心室缩功能的影响
Sten Lyager Nielsen1, Tomasz A Timek, G Randall Green
1Department of Cardiothoracic and Vascular Surgery and Institute of Experimental Clinical Research, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark.
Circulation
|July 16, 2003
概括
在绵羊中切断前肌,急性损害了插入部位附近的区域左心室 (LV) 缩功能. 这突出了切割手术的潜在风险,用于在受损的心室中进行 mitrale regurgitation.
科学领域:
- 心血管生理学心血管生理学
- 心脏机械学 心脏机械学
- 手术创新 在外科创新.
背景情况:
- 在左心室 (LV) 缩力学中,前额叶片第二阶段状肌脉的作用仍在争论中.
- 了解这种贡献对于开发有效的心脏病治疗方法至关重要.
研究的目的:
- 量化前肌 (ACT) 和后肌 (PCT) 对区域和全球LV收缩功能的体内贡献.
- 评估切断这些chordae对LV机械的急性影响.
主要方法:
- 放射性不透明标记物植入绵羊LV上心部,以确定12个区域.
- 微微的力传感器在ACT和PCT中测量了弦张力.
- 血液动力学数据和区域功能 (分数面积缩小,r-PRSW) 在切割 (CUT) 之前和之后记录.
主要成果:
- 全球LV缩功能在CUT后没有受到影响.
- 分数区域收缩 (FAS) 在PCT插入点附近的LV段下降.
- 区域PRSW (r-PRSW) 在ACT和PCT插入点附近显著下降.
- 后肌 (PCT) 的最大张力比前肌 (ACT) 的最大张力高.
结论:
- 前叶片支柱的急性分裂导致了在带插入部位的区域LV静脉缩功能障碍.
- 涉及切割二阶的手术需要谨慎,特别是在心室中具有先前存在的损伤.
- 这些发现表明,在此类干预后,LV缩功能可能受到损害.
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