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相关概念视频

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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在对骨肌肉缺血症的反应中,胚胎刺途径的产后复述.

Roberto Pola1, Leona E Ling, Tamar R Aprahamian

  • 1Department of Medicine (Cardiovascular Research), St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Mass 02135-2997, USA.

Circulation
|July 16, 2003
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概括

刺 (Hh) 信号通路在受伤后的成年肌肉中活跃,在再生过程中促进血管生长 (血管生成). 阻止Shh会阻碍这一关键的愈合过程.

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科学领域:

  • 发展生物学 发展生物学
  • 再生医学是一种再生医学.
  • 分子信号传输的方法

背景情况:

  • 刺 (Hh) 蛋白质是胚胎发育中的关键形态原体,调节细胞信号传递.
  • 索尼克 (Shh),印度 (Ihh) 和沙漠 (Dhh) 是人类的HH基因,通过补丁 (Ptc1) 受体转化.
  • 众所周知,外源性SHH的使用可诱导血管生成.

研究的目的:

  • 调查内源性Hh通路在成年人缺血后肌肉再生中的作用.
  • 为了确定Hh信号是否有助于受伤的成年肌肉组织的血管生成.

主要方法:

  • 在缺血骨肌中分析Shh mRNA和蛋白质表达.
  • 在间歇性介质细胞中Ptc1受体激活的评估.
  • 在缺血条件下的血管内皮生长因子 (VEGF) 生产的评估.
  • 使用阻断抗体抑制SHH通路.

主要成果:

  • 骨肌肉缺血强烈上调局部Shh mRNA和蛋白质.
  • Ptc1受体的激活证实了在缺血区Shh通路的功能.
  • 在缺血期间,SHH-响应细胞产生VEGF.
  • Shh通路的抑制降低了血管生成和VEGF上调.

结论:

  • Hh信号通路在成年人中是活跃的,分化肌肉组织在出生后.
  • 在缺血后肌肉再生期间,Hh信号在血管生成中起着调节作用.
  • 这些发现揭示了Hh途径具有治疗潜力的新生物学活性.