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Updated: Feb 6, 2026
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Protein Modifications: Protein Kinases and Phosphatases
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患有严重急性呼吸系统综合征的危急病患者
Robert A Fowler1, Stephen E Lapinsky, David Hallett
1Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario.
JAMA
|July 17, 2003
概括
严重急性呼吸系统综合征 (SARS) 严重影响了19%的患者,在重症监护室 (ICU) 死亡率为34%. 此外,SARS也压迫了重症监护资源,并导致医疗保健工作者感染.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 严重急性呼吸系统综合征 (SARS) 是一种新型传染病,可导致严重呼吸系统衰竭.
- 了解重症SARS患者的特征对于管理疫情至关重要.
研究的目的:
- 确定与SARS相关的严重疾病患者的流行病学特征,临床过程和结果.
- 评估SARS对重症监护室 (ICU) 资源和医疗保健工作者 (HCW) 的影响.
主要方法:
- 从疫情开始到2003年4月15日,回顾38名与SARS相关的严重疾病的成年患者的病例系列,这些患者从疫情开始到2003年4月15日被送往多伦多地区的ICU.
- 在第一7天的ICU中,每天收集数据;患者被跟踪28天. 主要结局:28天死亡率.
主要成果:
- 在196名SARS患者中,38人 (19%) 病情危急;7人 (18%) 是高血压患者. 平均年龄为57.4岁.
- 二十九名 (76%) 需要机械通风,在这个群体中死亡率为45%. 整体28天死亡率为34%.
- 在ICU中SARS传播导致164名HCW的病床关闭和隔离,其中16人 (10%) 感染了SARS.
结论:
- 严重疾病在SARS患者中很常见,主要呈现为单个器官呼吸衰竭.
- 机械通风的SARS患者中有一半死亡,这凸显了呼吸系统损害的严重性.
- SARS 疫情显著削弱了区域重症监护能力,并给医疗保健工作者带来了风险.
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