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生活压力对抑郁症的影响:通过5-HTT基因的多态化来调节
Avshalom Caspi1, Karen Sugden, Terrie E Moffitt
1Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, PO80 De Crespigny Park, London, SE5 8AF, UK.
Science (New York, N.Y.)
|July 19, 2003
概括
压力较大的生活事件增加了抑郁症的风险,但遗传学也起到了作用. 血清素载体 (5-HT T) 基因
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 压力较大的生活事件是抑郁症的已知危险因素.
- 个人对压力的反应有很大差异,这表明了潜在的缓和因素.
- 人们越来越认识到遗传倾向会影响心理健康结果.
研究的目的:
- 调查遗传因素在缓解压力生活事件和抑郁症之间的关系中的作用.
- 为了确定影响压力后易患抑郁症的特定基因变异.
- 探索基因与环境相互作用在抑郁症发展中的概念.
主要方法:
- 展望-纵向研究设计.
- 对一个代表性的出生队列的分析.
- 在血清素载体 (5-HT T) 基因促进区的功能多态性基因定型.
- 评估抑郁症状,诊断抑郁和自杀倾向与报告的压力生活事件相关的情况.
主要成果:
- 血清素载体 (5-HT T) 基因促进体中的功能多态性显著缓解了压力生活事件对抑郁症的影响.
- 具有1或2个5-HT T促销物多态性短等位基因拷贝的个体在经历过压力生活事件后,表现出抑郁症状,抑郁症诊断和自杀倾向的增加.
- 对于长等位基具有同异位基的个体,不太容易受到压力生活事件的抑郁影响.
结论:
- 证据支持抑郁症的基因与环境相互作用模型.
- 血清素载体 (5-HT T) 基因多态化是影响个体易受压力诱导抑郁症的关键因素.
- 基因构成显著减轻环境因素对心理健康的影响.
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