西尼罗病毒感染的神经症状和结果
James J Sejvar1, Maryam B Haddad, Bruce C Tierney
1Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, and Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA. zea3@cdc.gov
JAMA
|July 24, 2003
概括
西尼罗河病毒 (WNV) 感染可能导致严重的神经问题,包括运动障碍和. 虽然脑膜炎和脑炎患者通常会康复,但急性松性可能导致肢体不可逆转的衰弱.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 西尼罗病毒 (WNV) 感染的神经学表现需要潜在的特征.
- 关于WNV患者的实验室发现和结果的数据有限.
研究的目的:
- 为了前性地记录WNV感染的临床和实验室特征.
- 评估WNV患者的长期神经学结果.
主要方法:
- 2002年8月1日至9月2日,在路易斯安那州圣塔玛尼教区进行了一系列前性案例.
- 对于怀疑的WNV病例,收集了标准化的临床数据.
- 已确认WNV阳性患者在8个月后进行了重新评估.
主要成果:
- 在39例疑似病例中,有16例 (37%) 呈WNV血清阳性,出现脑膜炎 (5),脑炎 (8),或急性性 (3).
- 运动障碍,如震 (94%),帕金森症 (69%) 和肌 (31%) 是常见的.
- 在8个月后,注意到持续的疲劳,头痛,肌痛和步行/运动障碍;急性松性患者没有恢复四肢力量.
结论:
- 在急性疾病期间,WNV感染可以表现为显著的运动障碍.
- 患有WNV脑膜炎或脑炎的患者可能会获得有利的长期结果.
- 由于WNV引起的急性松性会导致一种不可逆转的类似于脊髓灰质炎的综合征.
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