人类细胞巨乳病毒的血清阳性与血管功能受损有关
Cairistine Grahame-Clarke1, Norman N Chan, Dawn Andrew
1Department of Epidemiology and Public Health, University College London, 5 University St, London, WC1E 6JJ, UK.
Circulation
|August 6, 2003
概括
细胞巨乳病毒 (CMV) 感染与内皮功能障碍有关,这是动脉样硬化的前体. 这种关联独立于传统的危险因素,可能会增加动脉样硬化的负担.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 血管生物学 血管生物学
背景情况:
- 疹病毒感染,包括细胞巨乳病毒 (CMV) 和简单疹病毒 (HSV),是导致动脉样硬化的潜在因素.
- 内皮功能障碍是动脉样硬化的早期指标,糖尿病患者的风险可能更高.
研究的目的:
- 调查之前的CMV和HSV感染与内皮功能障碍之间的关联.
- 为了确定这种关联是否在糖尿病患者中更明显.
主要方法:
- 在400名受试者中评估了CMV和HSV的抗IgG抗体,包括糖尿病患者和非糖尿病患者.
- 使用电子束计算断层扫描量化冠状动脉动脉瘤.
- 通过使用各种血管活性剂进行静脉封闭囊造影测量内皮功能.
主要成果:
- 具有CMV病毒阳性个体对布拉迪基宁和甘三酸盐的血管反应减少.
- 在调整为甘三酸盐反应后,对布拉迪基宁的受损反应仍然显著,并且独立于常规风险因素.
- 在糖尿病人和非糖尿病人之间没有观察到内皮功能障碍的显著差异.
结论:
- 冠状病毒病毒阳性与内皮功能障碍和氧化物 (NO) 反应受损有关.
- 这种联系与传统的心血管风险因素是独立的.
- 冠状动脉病毒感染可能导致动脉样硬化负担增加.
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