怀孕:一个克隆马出生于其双胞胎
Cesare Galli1, Irina Lagutina, Gabriella Crotti
1Laboratorio di Tecnologie della Riproduzione, CIZ srl, Istituto Sperimentale Italiano Lazzaro Spallanzani, 26100 Cremona, Italy. cesare@galli2.191.it
Nature
|August 9, 2003
概括
身体细胞克隆成功地产生了一种基因相同的马克隆. 克隆小被自己的核捐赠者携带到期,挑战了关于怀孕结果的现有理论.
科学领域:
- 生殖生物学 生殖生物学
- 动物克隆动物克隆
- 马科的科学 马科的科学
背景情况:
- 在各种动物物种中,体细胞克隆已经取得了成功.
- 克隆包括将核材料转移到无核卵细胞中,以创建一个遗传副本.
研究的目的:
- 通过体细胞核转移克隆成年马.
- 调查代孕母亲同时也是核捐赠者的可行性.
主要方法:
- 在一个成年马身上进行了体细胞核转移.
- 在核供体母马中确立了一个可行的,长期怀孕.
- 由此产生的后代是代孕母亲的遗传副本.
主要成果:
- 一匹健康的,长寿的克隆马被制造出来.
- 克隆的马在遗传上与它所携带的马匹完全相同.
- 这挑战了关于母亲与胎儿免疫相互作用的既定概念.
结论:
- 通过体细胞核转移,可以实现成功的马类克隆.
- 母亲和后代之间的遗传身份并没有对怀孕产生负面影响.
- 这表明,母亲的免疫学识别可能不是所有怀孕中的关键因素.
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