确定细胞分裂平面的位置
Julie C Canman1, Lisa A Cameron, Paul S Maddox
1University of North Carolina, Department of Biology, 607 Fordham Hall, CB #3280, Chapel Hill, North Carolina 27699-3280, USA.
Nature
|August 9, 2003
概括
细胞分裂平面的定位对发育至关重要. 这项研究表明,哺乳动物细胞细胞动能可以在没有双极的情况下发生,这挑战了以前的假设,并揭示了对细胞分裂机制的新见解.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 适当的细胞分裂平面定位对于细胞的发育和分化至关重要.
- 以前认为双极微管阵列对于哺乳动物细胞的位定位至关重要.
研究的目的:
- 为了调查双极是否需要在哺乳动物细胞中形成.
- 探索具有单极的细胞中细胞动力学机制.
主要方法:
- 诱导具有单极的哺乳动物组织细胞进入亚纳相.
- 在单极和双极中分析细胞动力学过程中微管的行为.
- 在被操纵的细胞中观察的形成和细胞运动的频率.
主要成果:
- 细胞动力学在具有单极的哺乳动物培养细胞中高频发生.
- 形不需要双极螺旋.
- 分裂始终发生在距离染色体的皮质位置.
结论:
- 双极的存在不是哺乳动物细胞中细胞运动的先决条件.
- 一个稳定的微管子子群延伸过去的染色体和与细胞皮层相互作用,参与了的形成.
- 染色体可能提供增强微管稳定性和促进的因素.
相关概念视频
Mitosis and Cytokinesis
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
The Phragmoplast
Cell division is essential for organismal growth and development. In animal cells, the central spindle and its associated proteins form the midbody, a structure that has an essential role in cytokinesis. In plants, the central spindle, along with the microtubules, actin, and other cell components, matures into the phragmoplast, which is necessary for cytokinesis. Unlike the stationary midbody, the phragmoplast expands centrifugally, eventually leading to the formation of the new cell wall.
The...
The...
Distribution of Cytoplasmic Content
Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Mitosis and Cytokinesis
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...


