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通过Sonic hedgehog抑制神经皮质补丁诱导的亡
Chantal Thibert1, Marie-Aimée Teillet, Françoise Lapointe
1Apoptosis/Differentiation Laboratory, "La Ligue," Molecular and Cellular Genetic Center, CNRS Unite Mixte Recherche (UMR) 5534, University of Lyon, 69622 Villeurbanne, France.
Science (New York, N.Y.)
|August 9, 2003
概括
声波刺 (Shh) 信号对脊髓发育至关重要. 未结合的补丁 (Ptc) 诱导细胞死亡,但Shh与Ptc结合促进细胞存活和分化,确保正确的神经管模式.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 分子信号传递是分子信号传递.
背景情况:
- 声波刺 (Shh) 是脊椎动物胚胎发育中的一个关键信号分子.
- Shh建立了神经管模式所必不可少的腹脊梯度.
- 沙也在神经上皮细胞的生存中发挥着关键作用.
研究的目的:
- 为了研究Patched (Ptc) 在Shh介导细胞存活中的作用.
- 阐明Shh调节神经上皮细胞命运的机制.
- 了解Ptc,Shh和脊髓发育中的亡之间的相互作用.
主要方法:
- 小胚胎模型系统.
- 对细胞死亡和分化标记物的分析.
- 对SHH信号通路的操纵.
主要成果:
- 补丁 (Ptc) 在缺少其连接体Sonic hedgehog (Shh) 的情况下诱导细胞死亡.
- 对Ptc的SHH结合抑制了这种亲细胞的活性.
- 阻断Ptc诱导的细胞死亡部分地拯救了由Shh剥夺引起的脊髓缺陷.
结论:
- 无结合Ptc的预位功能和Shh结合Ptc的细胞分化促进作用对于脊髓发育至关重要.
- 通过Ptc,SHH信号调节神经上皮细胞的生存和分化.
- Ptc在亡和分化中的这种双重作用对于正确的神经管形成至关重要.
相关概念视频
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01:30Apoptosis
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02:33Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...