纤维素因子的季节性变化在滴滴和非滴滴高血压患者中
Ramon C Hermida1, Carlos Calvo, Diana E Ayala
1Bioengineering and Chronobiology Laboratories, University of Vigo, Campus Universitario, Vigo, Spain. rhermida@tsc.uvigo.es
Circulation
|August 13, 2003
概括
血纤维素素显示季节性变化,在2月达到峰值. 非浸泡性高血压患者的纤维素水平较高,增加了他们的血管事件风险,特别是在冬季.
科学领域:
- 心血管医学 心血管医学
- 临床生物化学 临床生物化学
- 时间生物学 时间生物学
背景情况:
- 血纤维素是心肌梗塞和中风的风险标志物.
- 已经报告了血纤维素的季节性变化,冬季水平更高.
- 没有夜间血压下降 (nondipping) 与心血管事件增加有关.
研究的目的:
- 为了比较血纤维素的年均变化,滴水和非滴水高血压患者.
- 为了研究血压模式和季节性纤维素原变化之间的关系.
主要方法:
- 研究了1006名1-2期高血压患者 (平均年龄为53.0岁).
- 进行了48小时的门诊血压监测和手腕动图.
- 血纤维素水平被分析为Dipper和nondipper亚组的周年变化.
主要成果:
- 观察到血纤维素的显著季节性变化 (P<0.001),在2月达到峰值.
- 非Dipper患者 (n=513) 的血纤维素水平明显高于Dipper患者 (P<0.001).
- 纤维素原变化的周年幅度为40 mg/dL.
结论:
- 在非浸泡患者中血纤维素的升高与血管事件风险的增加有关.
- 在冬季末,这种风险似乎更高.
- 纤维素素和血压下降的季节性模式是心血管风险分层的关键因素.
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