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用于治疗高胆固醇血症的古古利皮德:一个随机对照试验
Philippe O Szapary1, Megan L Wolfe, LeAnne T Bloedon
1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA. szapary@mail.med.upenn.edu
JAMA
|August 14, 2003
概括
草本提取物Guggulipid在患有高脂血症的成年人中没有降低胆固醇,但可能会增加LDL胆固醇. 一些参与者出现了皮疹,这表明了潜在的安全问题.
科学领域:
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
- 心血管健康 心血管健康
背景情况:
- 康米花 (Commiphora mukul) 提取物在亚洲被用于降低胆固醇.
- 古古尔斯特,古古尔的活性化合物,对抗参与胆固醇代谢的核受体.
- 西方人群中guggul提取物的安全性和有效性数据有限.
研究的目的:
- 为了评估两剂古古脂的短期安全性和有效性.
- 评估古古脂对西方饮食中超脂血症的健康成年人脂质资料的影响.
主要方法:
- 一个双盲,随机,安慰剂对照试验,并行设计.
- 103名患有高胆固醇血的健康成年人接受标准剂量古古脂 (1000毫克),高剂量古古脂 (2000毫克) 或安慰剂口服每天三次,持续8周.
- 主要结果是低密度脂蛋白胆固醇 (LDL-C) 的百分比变化;次要结果包括其他脂质水平和安全措施.
主要成果:
- 在8周后,与安慰剂相比,古古利皮德治疗 (两剂) 增加了9-10%的LDL-C水平 (P=.01和P=.006).
- 没有观察到总胆固醇,HDL-C,甘油三或VLDL-C的显著变化.
- 格格脂的耐受性一般很好,但6名参与者出现过敏性皮疹.
结论:
- 在高脂症成年人中,古古利皮德在改善血清胆固醇水平方面没有显示短期有效性.
- 古格脂可能会增加LDL-C水平,并导致皮肤过敏反应.
- 需要进一步的研究来澄清古古的长期影响和安全性.
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