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一个依赖PLP的种族酶通过单个活性位子突变转化为阿尔多酶

Florian P Seebeck1, Donald Hilvert

  • 1Laboratorium für Organische Chemie, Swiss Federal Institute of Technology, ETH Hönggerberg, CH-8093 Zürich, Switzerland.

Journal of the American Chemical Society
|August 21, 2003
PubMed
概括

氨酸赛马酶 (Alr) 突变将其转化为一种高效的阿尔多酶. Y265A突变酶选择性地分裂β-氨酸,提供了对酶进化和细菌细胞壁合成的见解.

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