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在百万妇女研究中,乳腺癌和激素替代疗法
1Cancer Research UK Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK.
Lancet (London, England)
|August 21, 2003
概括
目前使用的激素替代疗法 (HRT) 显著增加了乳腺癌风险,特别是在雌激素-孕激素组合时. 过去使用HRT并没有增加风险,这突显了治疗类型对癌症发病率的重要性.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 激素替代疗法 (HRT) 与乳腺癌发病率的增加有关.
- 百万妇女研究的目的是澄清HRT对乳腺癌的具体影响.
研究的目的:
- 调查当前和过去使用激素替代疗法 (HRT) 与患乳腺癌和死于乳腺癌的风险之间的关联.
- 为了比较与不同类型的HRT制剂相关的风险.
主要方法:
- 在1996-2001年期间,招募了108,4110名50-64岁的英国女性.
- 收集关于HRT使用和个人信息的数据.
- 对乳腺癌发病率和死亡率进行了跟踪.
主要成果:
- 与从未使用者相比,当前HRT使用者患乳腺癌的风险增加 (RR 1.66) 和致命 (RR 1.22) 的风险增加.
- 雌激素-孕激素组合的风险明显高 (RR 2.00) 比仅用雌激素或提博龙的风险要大.
- 风险随着HRT使用的持续时间而增加; 估计10年的雌激素-孕激素HRT每1000名用户就会导致19种额外的癌症.
结论:
- 目前使用HRT与发生性和致命乳腺癌的风险增加有关.
- 与其他HRT类型相比,雌激素-孕激素组合的风险明显更高.
- 过去的HRT使用与乳腺癌风险增加无关.
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