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Updated: Jul 18, 2026

Protein Misfolding Cyclic Amplification of Prions
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通过对粉样蛋白形状的突变控制来产生子传输屏障

Peter Chien1, Angela H DePace, Sean R Collins

  • 1Graduate Group in Biophysics, University of California-San Francisco, San Francisco, California 94143-2240, USA.

Nature
|August 22, 2003
PubMed
概括

酵母蛋白Sup35p的突变改变了粉样蛋白种植特异性,创造了新的传播障碍. 这项工作解释了突变如何产生子屏障并影响蛋白质错折疾病中的毒性.

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