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相关概念视频

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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相关实验视频

Updated: Jul 10, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

伊马替尼布用于全身性巨细胞疾病.

A Pardanani1, M Elliott, T Reeder

  • 1Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Lancet (London, England)
|August 23, 2003
PubMed
概括

伊马替尼有效地通过向c-kit来治疗全身性乳腺细胞疾病. 50%的患者表现出显著的反应,有些人实现了完全缓解,突出显示伊马替尼布.

科学领域:

  • 血液学 血液学 血液学
  • 在瘤学瘤学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 系统性乳腺细胞疾病 (SMCD) 是一种罕见的疾病,通常是由c-kit原型瘤基因的突变驱动的.
  • 伊马替尼是已知的氨酸激酶抑制剂,向c-kit,并在某些恶性瘤中显示出有效性.

研究的目的:

  • 为了评估伊马替尼的疗效和安全性,成年患者有症状的全身性巨细胞疾病.
  • 评估不同剂量的伊马替尼布治疗患者的应答率和临床结果.

主要方法:

  • 一项前性研究涉及12名患有症状SMCD的成年患者.
  • 患者接受了每日100毫克或400毫克剂量的意马替尼.
  • 通过临床,组织学和血液学参数来评估反应,包括巨细胞细胞减少和eosinophilia.

主要成果:

  • 50% (10名可评估患者中5名) 显示对伊马替尼布有可测量的反应.
  • 四名患者实现了显著的巨细胞细胞减少,两名患者实现了完全的临床和组织学缓解.
  • 五分之三的eosinophilia患者实现了完全的临床和血液学缓解. 没有反应的人拥有c-kit D816V突变.

结论:

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Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish
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Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

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Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension
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Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

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Last Updated: Jul 10, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish
09:39

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Published on: December 26, 2014

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension
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Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Published on: March 1, 2024

  • 伊马替尼在全身性巨细胞疾病中表现出显著的临床活性.
  • 该药物似乎对野生类型的c-kit驱动疾病有效,对携带c-kit D816V突变的患者有效性有限.
  • 伊马替尼可能会抑制野生型c-kit的增长促进作用或向SMCD中的其他瘤性激酶.