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Updated: Jul 10, 2026

Visualization of Bacterial Toxin Induced Responses Using Live Cell Fluorescence Microscopy
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Published on: October 1, 2012

杆菌的真空化细胞毒素抑制T淋巴细胞的激活

Bettina Gebert1, Wolfgang Fischer, Evelyn Weiss

  • 1Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, LMU München, Germany.

Science (New York, N.Y.)
|August 23, 2003
PubMed
概括

杆菌的真空化细胞毒素 (VacA) 通过阻止细胞循环来阻止T细胞的增殖. VacA干扰免疫信号通路,可能解释慢性H. pylori感染.

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...