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在激活一个enediyne时的 conformational控制

M F Semmelhack1, Lingyun Wu, Robert A Pascal

  • 1Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. mfshack@princeton.edu

Journal of the American Chemical Society
|August 28, 2003
PubMed
概括

计算研究预测bicyclo[7.3.1]tridec-4-ene-2,6-diyne的椅子构造器更具反应性. 合成一个桥接衍生品证实了这一点,显示引发了enediyne毒素的循环芳香化.

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