相关概念视频
01:45Positive Regulator Molecules
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
02:39Positive Regulator Molecules
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
02:34Inhibition of Cdk Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
02:38S-Cdk Initiates DNA Replication
The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.
02:34Inhibition of CDK Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
02:38S-Cdk Initiates DNA Replication
The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.
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没有环林E-CDK2的细胞增殖.
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Cell
|August 28, 2003
概括
小鼠可以在没有循环蛋白E1和E2的情况下发育,但这些蛋白质对于细胞循环的进展至关重要. 具体来说,环林E1和E2对于小鼠细胞的内复制和退出静止是必不可少的.
科学领域:
- 细胞生物学 细胞生物学
- 发育生物学是发展生物学.
- 分子遗传学分子遗传学
背景情况:
- 环素是细胞循环的关键调节剂.
- 已知循环E蛋白 (E1和E2) 在细胞增殖中起作用.
- 环林E1和E2在哺乳动物胚胎发育和细胞循环结束中的特定必要性尚未完全阐明.
研究的目的:
- 调查环林E1和E2在小鼠胚胎发育中的作用.
- 确定循环素E1和E2在纤维细胞增殖中的作用.
- 评估循环素E1和E2对内核复制和退出静止状态的要求.
主要方法:
- 产生缺乏环素E1和环素E2基因的小鼠 (双淘汰赛).
- 从双重淘汰胚胎中获得的纤维细胞培养和分析.
- 在野生类型和淘汰细胞中评估细胞增殖,内复制和静止退出.
主要成果:
- 缺乏E1和E2环林的小鼠可以完成胚胎发育.
- 双淘汰赛胚胎中的纤维细胞在体外表现出正常的增殖.
- 环E1和E2对于内核复制和从静止状态过渡到活跃细胞循环是不可或缺的.
更多相关视频
08:33Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
Published on: December 5, 2017
12:26Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
结论:
- 环E1和E2对于胚胎发育或基本纤维细胞增殖并不重要.
- 这些特定的环林在细胞周期的特殊过程中起着关键的作用,即内复制和退出静止状态.