相关实验视频
Updated: Jul 13, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
提供肺炎球菌预防措施,对有状细胞疾病的公共保险儿童提供肺炎球菌预防
Colin M Sox1, William O Cooper, Thomas D Koepsell
1Department of Pediatrics, University of Washington, Seattle 98195-7183, USA. colinsox@u.washington.edu
患有状细胞疾病 (SCD) 的儿童往往没有得到足够的抗生素预防,增加了感染风险. 预防性护理访问与这些脆弱儿童更好地提供药物相关.
科学领域:
- 儿童传染病 儿童传染病
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 患有状细胞疾病 (SCD) 的5岁以下儿童需要每天服用预防性抗生素来预防肺炎球菌感染.
- 对这些儿童分发的预防药物的实际量尚不清楚.
研究的目的:
- 量化SCD的幼儿的预防性抗生素处方.
- 确定影响这些必需药物的提供因素.
主要方法:
- 使用田纳西州和华盛顿州的医疗补助行政索赔 (1995-1999年) 的回顾性纵向研究.
- 包括261名患有SCD的4岁以下儿童,连续注册医疗补助一年.
- 在365天的时间内,针对特定抗生素的处方填充所涵盖的测量日.
主要成果:
- 患者平均每年接受148.4天的预防药物治疗,差异很大 (10.3%没有接受,21.5%接受>270天).
- 每名患者平均每年填写12.7份处方,平均持续时间为10天.
- 每次预防性访问与12.0个额外的抗生素日有关,每次ED访问与10.0个额外的日有关.
结论:
- 公共保险儿童患有SCD可能有不充分的抗生素预防,增加肺炎球菌感染发病率和死亡率的风险.
- 门诊预防性护理访问的增加与SCD儿童抗生素预防措施的改善有关.
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