儿童时期的脏病综合征
Allison A Eddy1, Jordan M Symons
1Department of Pediatrics, University of Washington, Children's Hospital and Regional Medical Center, Seattle, WA 98105, USA. allison.eddy@seattlechildrens.org
Lancet (London, England)
|August 29, 2003
概括
儿童性综合征,主要是最小变化的性综合征和焦点细分质硬化症,往往源于未知原因,但涉及细胞功能障碍. 治疗涉及皮质类固醇,根据类固醇反应的不同预后.
科学领域:
- 儿科脏病学 儿科脏病学
- 淋巴细胞疾病 淋巴细胞疾病
- 免疫学 免疫学 免疫学
背景情况:
- 儿童性综合征通常呈现为最小变化性综合征 (MCNS) 或焦点细分质硬化症 (FSGS).
- 罕见的原因包括遗传性疾病,药物毒性,感染和瘤.
- 假设异常性性综合征涉及T细胞功能障碍影响淋巴细胞 podocytes.
研究的目的:
- 审查儿童综合征的原因,病原和治疗方法.
- 为了突出类固醇反应对脏组织学的预后意义.
- 讨论并发症和当前的研究方向.
主要方法:
- 在儿童的异形性性综合征的文献综述.
- 对涉及 podocyte 蛋白质突变的遗传研究进行分析.
- 目前治疗策略及其有效性的总结.
主要成果:
- 类固醇反应是异常性性综合征的关键预后因素.
- 对于耐火病例,使用二线疗法,如基化剂和氨酸抑制剂.
- 并发症包括感染和血栓栓塞;耐火性FSGS往往导致末期病.
结论:
- 儿童性综合征需要根据组织学和类固醇反应量身定制的管理.
- 需要进一步的研究,以了解分子病原体和改善治疗.
- 早期识别并发症和管理对于患者的治疗结果至关重要.
相关概念视频
Classification of Illness
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
Psychosexual Stages of Personality: Anal
Sigmund Freud's theory of psychosexual development describes the anal stage as occurring between 18 months and three years of age. During this period, children derive pleasure from controlling and releasing their bowel movements. However, they quickly learn that societal expectations impose restrictions on when and where this can happen. This stage marks a critical point where children begin to develop a sense of control and mastery over their bodily functions, as well as their broader...
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Bulimia Nervosa
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Oppositional Defiant Disorder
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
Conduct Disorder
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...

