血清粉样蛋白在阻塞性睡眠呼吸暂停中的作用
Anna Svatikova1, Robert Wolk, Abu S Shamsuzzaman
1Mayo Foundation, Rochester, Minn, USA
Circulation
|September 4, 2003
概括
患有中度至重度阻塞性睡眠呼吸暂停 (OSA) 的患者血清粉样蛋白A (SAA) 蛋白水平显著提高. 这些升高的SAA水平可能会增加OSA患者心血管和脑血管疾病的风险.
科学领域:
- 心血管医学 心血管医学
- 睡眠医学 睡眠医学
- 生物化学 生物化学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与心血管和脑血管疾病风险增加有关.
- 血清粉样蛋白A (SAA) 蛋白与动脉样硬化,中风,糖尿病和痴呆症有关.
- 在SAA水平和OSA之间的关系需要进一步调查.
研究的目的:
- 为了测试血SAA水平在OSA的健康个体中升高的假设.
- 为了比较中度至重度OSA,轻度OSA和健康对照患者的SAA水平.
- 探索SAA水平与OSA严重程度之间的相关性.
主要方法:
- 血SAA水平测量在男性和女性患者中度至重度的OSA,轻度的OSA和匹配的对照.
- 测量是在睡觉前,经过5小时未经治疗的OSA后,并在持续的正气道压力 (CPAP) 治疗后的早晨进行的.
- 呼吸暂停-呼吸暂停指数 (AHI) 用于评估OSA的严重程度.
主要成果:
- 与对照组相比,中度至重度OSA患者的血SAA水平显著更高 (18.8比7.2微克/毫升,P=0.005).
- 轻度OSA患者的SAA水平与对照组相比较 (P=0.46).
- 在中度至重度的OSA中,男性和女性均观察到高SAA水平,与AHI正相关 (r=0.40,P=0.03).
结论:
- 血SAA水平在中度至重度OSA患者中是两倍以上,不论性别.
- 升高的SAA可能会导致OSA患者心血管和神经功能障碍的风险增加.
- 这些发现凸显了SAA作为OSA相关并发症的潜在生物标志物.
更多相关视频
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
04:53Acupoint Application Combined with Ear Plaster Therapy for Treating Sleep Disorders with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Published on: October 18, 2024
相关概念视频
Sleep-Wake Cycles
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Hyperpnea and Hyperventilation
Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
Stages of Sleep
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
REM Sleep Behavior Disorder
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
Narcolepsy
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
