针对儿童和青少年自闭症症状领域的向治疗
Eric Hollander1, Ann T Phillips, Chin-Chin Yeh
1Seaver and New York Autism Center of Excellence, Mount Sinai School of Medicine, New York, NY 10029, USA. eric.hollander@mssm.edu
Lancet (London, England)
|September 6, 2003
概括
选择性血红素反吸收抑制剂和非典型抗精神病药物在治疗自闭症谱系障碍 (ASD) 中具有挑战性的行为方面表现有前途. 需要进一步的研究来平衡治疗的益处与风险,并探索对发展的影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自闭症谱系障碍 (ASD) 的患病率正在上升,这给家庭和医疗保健专业人员带来了挑战.
- 在ASD中存在问题的行为需要有效的管理策略.
- 药理干预提供了针对特定ASD症状领域的潜力.
研究的目的:
- 审查自闭症谱系障碍药理疗法的现状.
- 讨论ASD干预的临床试验设计的进展.
- 确定ASD治疗策略的未来方向.
主要方法:
- 对ASD药理疗法的现有文献的审查.
- 对选择性血清素再吸收抑制剂 (SSRI) 和非典型抗精神病药物研究的分析.
- 讨论ASD临床试验方法的进展.
主要成果:
- 初步数据表明,SSRI,如citalopram,可能会减少自闭症患者的重复行为和情绪障碍.
- 利斯佩里是一种非典型的抗精神病药物,在减少ASD儿童的严重行为问题方面表现出有效性.
- 改进的研究设计允许更客观地评估ASD治疗疗效.
结论:
- 在ASD药物治疗中,平衡治疗毒性风险与症状严重性的好处至关重要.
- 关于患者特定治疗的知情决策越来越有可能.
- 未来的研究应该评估其他症状领域,发育效应和ASD学龄前干预措施.
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