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Re-Arterialized Rat Partial Liver Transplantation with an in vivo Vessel-Oriented 70% Hepatectomy
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通过 CalC 自我牺牲对 enediyne 抗瘤抗生素的耐药性

John B Biggins1, Kenolisa C Onwueme, Jon S Thorson

  • 1Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA.

Science (New York, N.Y.)
|September 13, 2003
PubMed
概括

细菌通过一种新的自我抵抗机制来逃避强大的抗生素. 这种自我牺牲的策略可以保护人免受高度反应性的内迪因化合物,为抗生素耐药性提供了新的见解.

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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