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转基因小鼠乳腺瘤病毒超抗原表达防止病毒感染

T V Golovkina1, A Chervonsky, J P Dudley

  • 1Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.

Cell
|May 15, 1992
PubMed
概括

小鼠乳腺瘤病毒 (MMTV) ORF蛋白质在转基因小鼠中删除特定的T细胞,防止病毒感染. 这表明内源性MMTV赋予对外源性MMTV感染的免疫力.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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