Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jul 16, 2026

An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents
10:36

An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents

Published on: September 24, 2014

在实验室中,赫比安抑制了孤立的神经肌肉突触.

Y Dan1, M M Poo

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027.

Science (New York, N.Y.)
|June 12, 1992
PubMed
概括

在外围突触中观察到突触可塑性或Hebbian调制. 仅仅 postsynaptic 活动就导致了突触抑郁,需要的流入,并暗示了逆行信号.

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Author Correction: Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's disease.

NPJ Parkinson's disease·2024
Same author

Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's disease.

NPJ Parkinson's disease·2024
Same author

Lithium chloride promotes neural functional recovery after local cerebral ischaemia injury in rats through Wnt signalling pathway activation.

Folia morphologica·2022
Same author

[Four cases of childhood lymphoma onset with cranial nerve involvement].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2022
Same author

Biomechanical study on different lengths of PFNA fixation for unstable intertrochanteric femoral fractures.

Journal of musculoskeletal & neuronal interactions·2017
Same author

Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus.

Scandinavian journal of rheumatology·2010

科学领域:

  • 神经科学是一个神经科学.
  • 突触性可塑性 突触性可塑性
  • 细胞和分子生物学 细胞和分子生物学

背景情况:

  • 突触效率调节对于神经功能至关重要.
  • 在突触调制中,先前和后突触活动之间的时间相关性的作用尚未完全理解,特别是在外围突触.

研究的目的:

  • 为了研究前和后突触活动之间的时间相关性对孤立神经肌肉突触中的突触有效性的影响.
  • 确定活动依赖突触调制的潜在机制.

主要方法:

  • 实验是在培养中孤立的神经肌肉突触上进行的.
  • 乙胆脉冲被应用在后突触,有或没有异步前突触活动.
  • 同时测试了同步的前和后突触协活性.
  • 测量了引起的发射器释放和 postsynaptic 细胞质的度.

主要成果:

  • 重复的 postsynaptic 乙胆的应用,单独或与异步的前性活动,诱导了立即和持久的突触抑郁.
  • 同步的前和后突触联合激活没有导致突触抑郁.
  • 突触抑郁是由于唤起的发射器释放减少.
  • 诱导突触抑郁需要增加突触后细胞质的度.

结论:

  • 赫比安调制是一种突触可塑性的形式,在体外孤立的外周突触中运作.
  • 超突触逆行相互作用被认为是这种突触抑郁的关键机制.
  • 在这些突触处诱导赫比安调制时, postsynaptic流入是必不可少的.

更多相关视频

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

Functional Isolation of Single Motor Units of Rat Medial Gastrocnemius Muscle
06:54

Functional Isolation of Single Motor Units of Rat Medial Gastrocnemius Muscle

Published on: December 26, 2020

相关实验视频

Last Updated: Jul 16, 2026

An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents
10:36

An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents

Published on: September 24, 2014

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

Functional Isolation of Single Motor Units of Rat Medial Gastrocnemius Muscle
06:54

Functional Isolation of Single Motor Units of Rat Medial Gastrocnemius Muscle

Published on: December 26, 2020