由小鼠II类主要基因相容性复杂分子I-Ad向免疫系统呈现的
D F Hunt1, H Michel, T A Dickinson
1Department of Chemistry, University of Virginia, Charlottesville 22901.
概括
研究人员确定了由主要基因相容性复合体II类分子I-Ad结合的特定序列. 这些源于抗原呈现细胞,具有独特的结合基因.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 主性基因相容性复合体 (MHC) II类分子为T辅助细胞呈现,在适应性免疫中发挥关键作用.
- 了解由MHCII类分子结合的的谱系对于破译免疫反应至关重要.
研究的目的:
- 为了确定天然与MHCII类分子I-Ad结合的的序列.
- 描述这些结合的结构特征和起源.
主要方法:
- 用于N端序列的自动化Edman降解.
- 双重质谱 (MS/MS) 用于的识别和测序.
- 分析的长度,端子和内部结合基因.
主要成果:
- 9个与I-Ad相关联的的测序.
- 鉴定由抗原呈现细胞合成的分泌或整体膜蛋白衍生的.
- 类是16-18个长度的残留物,具有可变的N-和C-末端.
- 在酸中确定了一种保存的六余结合基因.
- 具有约束力的数据表明,MHC II 类酸结合槽在两端都可访问.
结论:
- 由I-Ad呈现的类谱包括来自特定蛋白质类的自我衍生.
- 识别的结合动机为I-Ad的特异性提供了洞察力.
- 酸结合槽的开放性质会影响酸结合和呈现.
相关概念视频
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Diversity of Antigen Receptors
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...


