动态炼期间的同情和免疫相互作用. 通过β2上腺素依赖机制进行调解
D R Murray1, M Irwin, C A Rearden
1Department of Medicine, University of California San Diego.
Circulation
|July 1, 1992
概括
急性运动通过β2受体动员免疫细胞,影响免疫功能. 甲醇阻断了这些效应,而甲醇没有,这表明β2介导的交感神经系统与免疫系统的相互作用.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
背景情况:
- 同情神经系统和免疫功能之间的相互作用尚未完全理解.
- 之前的研究表明,catecholamines通过β2受体影响淋巴细胞循环.
研究的目的:
- 为了研究急性交感刺激是否影响免疫细胞流动和通过β2受体的功能.
- 确定β2-上腺素受体在运动诱导的免疫反应中的作用.
主要方法:
- 健康的志愿者接受了详尽的炼 (布鲁斯方案) 之前和之后的β阻断剂治疗 (propranolol或metoprolol).
- 循环淋巴细胞子集 (Ts / c,NK,T辅助细胞,B细胞) 和免疫功能 (IL-2受体表达,增殖,NK活性) 被测量.
- 对比了非选择性β-对抗剂propranolol和β1-选择性对抗剂metoprolol对运动诱导的变化的影响.
主要成果:
- 耗尽的运动诱导显著的淋巴细胞病变,特别是T抑制/细胞毒性 (Ts/c) 和自然杀手 (NK) 细胞.
- 运动改变了免疫功能,降低了IL-2受体表达和增殖,同时增强了NK细胞活性.
- 甲醇治疗使运动诱导的 Ts/c 和 NK 细胞的增加和免疫功能变化变得模糊.
- 梅托普罗洛尔治疗没有影响运动诱导的免疫参数变化.
结论:
- 通过运动的急性同情刺激可以选择性地释放免疫调节细胞.
- 这些运动诱导的免疫变化是由β2-上腺素受体介导的.
- 普罗普拉诺洛尔减弱了这些效应,与梅托普罗洛尔不同的是,它支持了在同情免疫相互作用中的β2介导机制.
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