在20世纪80年代,针对白血病的所有原骨髓移植的变化趋势在20世纪80年代发生了变化
M M Bortin1, M M Horowitz, R P Gale
1International Bone Marrow Transplant Registry, Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
JAMA
|August 5, 1992
概括
骨髓移植实践在20世纪80年代得到了改进,导致无白血病生存率略有提高. 这些进展主要是由于治疗死亡率降低,而不是复发率降低,突出显示了需要更好的抗白血病策略.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学 移植医学
背景情况:
- 骨髓移植 (BMT) 是各种白血病的关键治疗方法.
- 20世纪80年代,BMT技术和患者管理发生了重大变化.
研究的目的:
- 分析20世纪80年代白血病患者的BMT实践和结果的趋势.
- 确定导致生存率变化的因素.
主要方法:
- 一项针对白血病的7788名BMT接受者的大规模回顾性分析.
- 来自国际骨髓移植登记处的数据从1980年至1989年的五个2年队列中进行了比较.
主要成果:
- 慢性骨髓性白血病的移植显著增加 (14%至35%).
- 使用与无关的捐赠者和无辐射制备方案的使用量大幅增加.
- 无白血病生存率有所改善,主要是由于治疗相关死亡率降低,对复发率的影响最小.
结论:
- 在20世纪80年代,BMT实践的改进,而不是患者选择,带来了更好的结果.
- 进一步的进展需要加强抗白血病策略和减少治疗毒性.
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