从MHCII类分子中分离出来的的剪切变体表明了序列动图
Rudensky AYu1, P Preston-Hurlburt, B K al-Ramadi
1ImmuLogic Pharmaceutical Corporation, Palo Alto, California 94304.
Nature
|October 11, 1992
概括
主体组织相容性复合体 (MHC) II 类分子结合特定的片. 分析显示,在这些结合中的特定位置保留了氨基酸残留物,形成了对T细胞识别至关重要的序列基因.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- T细胞识别了由主要基因相容性复合体 (MHC) 分子呈现的异性抗原.
- MHC等位基变体在结裂的氨基酸上有所不同,这影响了结合的特异性.
- 之前的研究已经在MHC I类相关中确定了等位基因特异性的结构动机.
研究的目的:
- 扩展与MHCII类分子相关的序列的分析.
- 为了识别MHCII类绑定中的保存的氨基酸残留物和序列基因.
- 了解这些动机对CD4 T细胞识别的影响.
主要方法:
- 对MHCII类相关序列的分析.
- 在序列内的特定位置识别保存的氨基酸残留物.
- 序列对齐,考虑到氨基末端的移位.
主要成果:
- 发现特定的氨基酸残留物发生在与特定的MHCII类分子结合的的特定位置.
- 这些保存的残留物形成的序列图案是MHCII类结合的特征.
- 这些图案的调整需要在氨基末端移动一个或两个位置.
结论:
- MHC II 类分子与表现为保存序列动图的结合.
- 这些图案是由特定位置的特定氨基酸残留物定义的.
- 识别的序列动图与CD4 T细胞识别有关,即使有自然的氨基末端转移.
相关概念视频
01:26Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
01:31Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...