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In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
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Published on: November 3, 2015

模仿血管细胞分化和脱分化的实验模型

R R Pauly1, A Passaniti, M Crow

  • 1Gerontology Research Center, National Institutes of Health, National Institute on Aging, Baltimore, Md. 21224.

Circulation
|December 1, 1992
PubMed
概括

像Matrigel这样的细胞外基质成分可以阻止内皮细胞的增殖,并促进平滑肌肉细胞的分化. 这表明了维持血管健康的新疗法目标.

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...