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Updated: Jul 17, 2026

Identification of Protein Complexes in Escherichia coli using Sequential Peptide Affinity Purification in Combination with Tandem Mass Spectrometry
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Published on: November 12, 2012

一个全基因组的方法来体内DNA-蛋白相互作用在大肠杆菌

M X Wang1, G M Church

  • 1Laboratory of Oncology Research, Wills Eye Hospital, Philadelphia, Pennsylvania.

Nature
|December 10, 1992
PubMed
概括

这项研究引入了一种全基因组方法,用于在体内通过蛋白质保护的DNA序列. 该技术使用甲基酶和甲基化敏感酶来绘制这些受保护区域的地图,揭示了对基因调节至关重要的蛋白质-DNA相互作用.

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