在患有恶性疾病的成年人中,无需进行保护隔离的全基性骨髓移植
J A Russell1, M C Poon, A R Jones
1Department of Medicine, Foothills Hospital, Calgary, Alberta, Canada.
Lancet (London, England)
|January 4, 1992
概括
骨髓移植 (BMT) 患者可以安全地放弃严格的保护隔离. 这项研究在没有隔离的情况下发现了类似的结果,这表明BMT接受者的住院时间减少了.
科学领域:
- 血液学 血液学 血液学
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 骨髓移植 (BMT) 需要免疫受损患者的护理.
- 保护性隔离是预防感染和移植与宿主疾病 (GvHD) 的标准.
- 严格的保护性隔离在 BMT 的有效性需要进一步的研究.
研究的目的:
- 评估保护性隔离在预防BMT后传染性并发症方面的好处.
- 评估在没有严格隔离的情况下管理的 BMT 患者的安全性和结果.
主要方法:
- 研究了一系列连续的50名患者,他们首次接受了针对恶性疾病的BMT治疗.
- 患者在标准单人房里接受护理,并为访客提供手部卫生协议.
- 追踪了包括感染,GvHD和死亡率在内的结果.
主要成果:
- 32%的患者出现了阳性细菌培养或焦点感染.
- 24%的人患有格拉姆阳性细菌病;没有发生格拉姆阴性或真菌感染.
- 34%的人患有II或III级急性GvHD,没有因感染或GvHD而死亡.
结论:
- 在某些环境中,BMT可以在没有严格的保护隔离的情况下安全地执行.
- 减少住院和标准护理可能是BMT患者可行的.
- 死亡率数据与使用严格隔离措施的机构相比较好.
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