印梅他辛和食后胆囊排空的方法
L J O'Donnell1, P Wilson, P Guest
1Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, UK.
Lancet (London, England)
|February 1, 1992
概括
非类固醇抗炎药物 (NSAIDs),如印米他辛,可以改善胆囊空气在患有胆结石疾病的患者. 这表明NSAIDs可以通过增强胆囊运动性来预防胆结石的形成.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胆结石疾病通常与胆囊排空受损有关.
- 非类固醇抗炎药物 (NSAIDs) 有时与预防胆结石有关,但机制尚不清楚.
研究的目的:
- 调查NSAIDs,特别是印米他辛,是否可以改善胆囊空气在患有胆结石疾病的患者.
- 为了确定这种效应是否在胆结石患者和健康个体之间有所不同.
主要方法:
- 进行了一项随机的,安慰剂控制的研究.
- 参与者接受了印梅他辛 (25毫克每天三次一周) 或安慰剂一周.
- 在两组中评估了食后胆囊排空情况.
主要成果:
- 在所有7名患有胆结石疾病的患者中,印米他显著改善了食后胆囊排空.
- 在正常胆囊功能的健康人群中,没有观察到对胆囊排空的显著影响.
结论:
- 无抗炎药物,如印米他辛,可以通过作为一种促进胆囊排空的 prokinetic 剂来防止胆结石的形成,从而改善胆囊排空.
- 观察到的效果是特定于胆囊功能受损的个体,表明有针对性的治疗机制.
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