在冈比亚儿童的严重疟疾中比较甲和洛昆
N J White1, D Waller, J Crawley
1Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Lancet (London, England)
|February 8, 1992
概括
阿尔特梅瑟提供了一个耐受良好的,快速的亲肠道治疗严重的儿童疟疾. 这项研究发现,在儿童中使用甲基是有效的,尤其是在克洛洛耐药的Plasmodium falciparum流行的地方.
科学领域:
- 热带医学 热带医学
- 儿童传染病 儿童传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 严重的Falciparum疟疾对全球儿童构成重大威胁.
- 之前关于阿尔特梅瑟功效的研究主要集中在成年人群中.
- 抗氨酸抗性Plasmodium falciparum的出现需要替代治疗方法.
研究的目的:
- 为了研究肌肉内甲在患有中度至重度虫疟疾的儿童的疗效和耐受性.
- 为了比较artemether在儿科疟疾治疗中的有效性与chloroquine的有效性.
- 为了评估artemether在儿科队列中的安全概况.
主要方法:
- 一项涉及冈比亚儿童中度或重度型疟疾的随机研究.
- 参与者接受了肌肉内甲或.
- 监测了寄生虫清除时间,临床,血液学和生物化学参数.
主要成果:
- 在中度严重的疟疾病例中,阿尔特美的寄生虫清除时间显著缩短,而克洛洛奎因的清除时间显著缩短.
- 在严重的疟疾病例中,两种治疗都被很好地容忍,幸存者之间治疗反应没有显著差异.
- 在治疗中没有观察到局部或全身毒性.
结论:
- 阿尔特梅瑟是一种安全且快速有效的亲肠道治疗儿童严重疟疾的药物.
- 它的有效性在具有耐克洛昆Plasmodium falciparum的地区特别有价值.
- 需要进一步调查在儿童疟疾管理中的作用.
关键词:
非洲 非洲 非洲在撒哈拉以南的非洲.年龄因素 年龄因素死亡原因 - 统计数据孩子孩子孩子孩子孩子孩子数据分析 数据分析人口结构因素 人口结构因素发展中国家 发展中国家疾病 疾病 疾病药物 - - 管理和剂量.药物 - - 药物动力学讲英语的非洲.评价 评价 评价检查和诊断 检查和诊断冈比亚 冈比亚 是一个国家.实验室检查和诊断的方法疟疾:疟疾是一种疾病.死亡率 死亡率 死亡率寄生性疾病 寄生性疾病人口人口的人口人口.人口特征 人口特征人口动态 人口动态研究方法研究方法研究方法学治疗方法 治疗方法西非 非洲 西非 非洲年轻人 年轻人 年轻人 年轻人 年轻人更多相关视频
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