急性和慢性可卡因使用对心脏的影响
1Heart Institute Research Department, Hospital of the Good Samaritan, Los Angeles, Calif. 90017.
Circulation
|February 1, 1992
概括
可卡因使用会引起显著的心脏毒性,导致心肌缺血,心脏病发作和心律失常. 了解这些影响对于认识到可卡因是心脏病的风险因素至关重要.
科学领域:
- 心脏病学 心脏病学
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 可卡因是一种强大的兴奋剂,具有已知的心脏毒性作用.
- 急性和慢性可卡因使用可以导致各种心血管异常.
- 可卡因的心血管风险往往没有被认识到,特别是在年轻的患者中.
研究的目的:
- 总结一下可卡因对心脏有毒的影响.
- 阐明可卡因诱导心脏毒性的背后机制.
- 讨论可卡因心脏毒性的潜在治疗策略.
主要方法:
- 对可卡因心脏毒性现有文献的综述.
- 对可卡因对心血管系统的生理和病理影响的分析.
- 讨论拟议的行动机制.
主要成果:
- 急性可卡因使用会抑制心肌收缩,降低冠状动脉血流,增加心率和血压,导致缺血或心脏病发作.
- 慢性可卡因使用可以加速动脉样硬化,引起肌细胞亡和纤维化,导致心肌病,并诱导左心室缩.
- 在急性和慢性使用者中观察到可卡因引起的心律失常和突然死亡.
- 机制包括通道阻塞和抑制甲醇胺再吸收,增加同情输出.
结论:
- 可卡因是各种心血管疾病的重要且往往未被认可的危险因素,包括心肌梗塞,心肌病和心律失常.
- 可卡因的心脏毒性源于它对离子通道和甲醇胺水平的影响.
- 对于可卡因心脏毒性的治疗选择有限且有争议,一些药物显示出急性作用的希望.
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