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在接受全方位肠道营养的儿童中摄入过多的
A A Moukarzel1, M K Song, A L Buchman
1Department of Pediatrics, UCLA School of Medicine.
Lancet (London, England)
|February 15, 1992
概括
对于接受全方位肠道营养 (TPN) 的儿童,推的摄入量可能过高. 研究表明,当前水平与功能下降有关,即使摄入量低于推值,也表明需要更低的补充剂.
科学领域:
- 儿科脏病学 儿科脏病学
- 营养科学 营养科学
- 临床化学 临床化学
背景情况:
- 专家机构建议在全方位肠道营养 (TPN) 的儿童每天摄入0.20微克/公斤.
- 评估这种推摄入量的适当性对于儿科患者的安全至关重要.
- 以前的研究还没有完全评估对TPN依赖儿童对功能的影响.
研究的目的:
- 评估当前接受TPN的儿童推的摄入量.
- 评估这些患者的摄入量,血清水平和功能 (GFR) 之间的关系.
- 为了确定TPN溶液中的补充是否有助于对脏产生不良影响.
主要方法:
- 研究了15名接受TPN的儿童,测量了摄入量,血清和用-111-DTPA清除率 (GFR) 测量摄入量.
- 将TPN患者的GFR和血清与非TPN对照进行比较.
- 停止补充剂,并在一年后重新评估患者,观察GFR和血清的变化.
主要成果:
- 与对照组相比,TPN治疗的儿童的GFR显著降低 (70相比110毫升/分钟/1.73米2),血清水平高出20-42倍.
- GFR与血清,每日摄入量,累积摄入量和TPN持续时间有显著的反相关性.
- 在停止服用补充剂后,血清减少,但GFR没有显著变化,没有出现缺乏症的迹象.
结论:
- 对接受TPN的儿童来说,推的腹腔摄入量可能过多.
- 血清水平升高,甚至低于推摄入量,与TPN患者的功能受损有关.
- 降低TPN溶液中的补充值是有必要的,以防止潜在的毒性.
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