在孕期第一季度暴露于后,对怀孕结果的前性多中心研究
S J Jacobson1, K Jones, K Johnson
1Department of Pediatrics and Pharmacology, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Lancet (London, England)
|February 29, 1992
概括
在怀孕早期使用碳酸并没有增加重大出生缺陷. 暴露于的婴儿出生时体重较高,这表明不是人类显著的原体. 建议进行仔细监测.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 甲状腺学 甲状腺学
背景情况:
- 碳酸是主要情绪障碍的关键治疗方法.
- 有关子宫内暴露和心脏形的担忧存在,特别是第一季度的埃布斯坦异常.
- 关于的致病作用的前性数据对于管理孕妇患者至关重要.
研究的目的:
- 评估在怀孕第一季度暴露于碳酸的婴儿中出现重大先天性形的风险.
- 为了比较暴露妊娠和对照之间的妊娠结果,包括形率和出生体重.
- 评估在怀孕期间持续疗法的安全性,对于有情感障碍的女性.
主要方法:
- 从美国和加拿大的原体信息中心招募的148名孕妇在第一季度使用的前性队列研究.
- 怀孕结果与年龄相匹配的对照进行比较.
- 评估主要的先天性形,包括通过胎儿心声图的心脏异常,以及出生体重.
- 对于138名参与者的妊娠结果进行了完整的随访.
主要成果:
- 在暴露组 (2.8%) 和对照组 (2.4%) 之间,主要先天性形发生率相似.
- 在组中,埃布斯坦异常的一个病例导致了妊娠终止;对照组中发生了一个心室隔膜缺陷.
- 与对照组相比,暴露于的婴儿的出生体重明显高 (p = 0.02),即使考虑到组中更高的吸烟率.
结论:
- 碳酸不是基于这项研究的发现被确定为人类显著的原体.
- 患有严重情绪障碍的妇女可以在怀孕期间继续治疗,并进行适当的产前查,包括II级超声波和胎儿心声学.
- 该研究支持继续使用来管理怀孕期间的情感障碍,并进行仔细监测.
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