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子病毒乳头瘤的回归和恶性转化与MHCII类基因的联系
R Han1, F Breitburd, P N Marche
1Unité des Papillomavirus, INSERM U190, Paris, France.
Nature
|March 5, 1992
概括
遗传因素影响人类乳头瘤病毒引起的病变的进展. 主要组织相容性复杂II类基因与形回归和子模型中的恶性转变有关.
科学领域:
- 免疫遗传学 免疫遗传学
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 人类乳头瘤病毒 (HPV) 通过前体病变引起癌症,免疫反应可能会调解回归.
- 免疫反应基因中的多态性可能解释了对HPV诱导病变的各种宿主反应.
- 子中的Shope papilomavirus作为研究HPV相关病变演变的模型.
研究的目的:
- 调查主要基因相容性复合体 (MHC) 和T细胞受体 (TCR) 基因中遗传多态性在子Shope乳头瘤病毒诱导的病变进化的作用.
- 识别与退行和恶性转变相关的特定遗传标记.
主要方法:
- 对Shope乳头瘤病毒感染子中MHC类I,MHC类II和TCRβ链基因的限制片长多态性 (RFLP) 的分析.
- 特定的RFLP碎片与临床结果 (回归或恶性转变) 的相关性.
主要成果:
- 在回归和特定的DRαEcoRI片段之间发现了显著的关联.
- 恶性转变的相对风险增加与DQα PvuII片段有关.
- 这些发现表明,MHCII类区域内的基因控制了Shope乳头瘤病毒感染的结果.
结论:
- 遗传因素,特别是在MHCII类区域内,在确定HPV诱导病变的进展或回归方面发挥着至关重要的作用.
- 该研究提供了有关动物模型中宿主对的进化和恶性转变的遗传控制的证据.
- 这凸显了免疫遗传因素在预防癌症和治疗HPV相关疾病的策略中的重要性.
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