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高剂量静脉注射免疫球蛋白治疗对血液风湿学的影响
1Department of Internal Medicine, University of Bern, Inselspital, Switzerland.
Lancet (London, England)
|March 14, 1992
概括
高剂量静脉注射免疫球蛋白 (IVIG) 治疗增加了血液粘度,可能会损害血液流动. 这种粘度变化可能会增加敏感患者中风和心脏病发作的风险.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 心血管科学 心血管科学
背景情况:
- 高剂量静脉注射免疫球蛋白 (IVIG) 治疗与已报告的中风事件有关.
- 了解IVIG对血液病的影响对于患者的安全至关重要.
研究的目的:
- 为了研究IVIG对影响血液流动的因素的影响.
- 检查IVIG对血粘度,血液粘度和红细胞聚合的影响.
主要方法:
- 在体外实验中,试验人员将不同度的IVIG添加到健康捐献者的血液和血中.
- 在IVIG治疗疗程 (24-54克/天) 中进行了体内评估,对4名免疫血小板缺血症 (ITP) 患者进行了评估.
主要成果:
- 输注IgG度与血和全血粘度的增加有很强的相关性,无论是体外还是体内.
- 在IVIG治疗后,血粘度超过了正常范围.
- 红细胞聚合也受到IVIG的影响.
结论:
- 通过IVIG治疗可以显著改变血液粘度,可能会损害血液流动.
- 这些血液变化可能会增加心血管和血栓栓塞事件的风险,包括中风和心肌梗塞,在高危人群中.
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