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相关概念视频

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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相关实验视频

Updated: Jun 30, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

基因治疗癌症的基因治疗.

A A Gutierrez1, N R Lemoine, K Sikora

  • 1Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Lancet (London, England)
|March 21, 1992
PubMed
概括

基因转移通过向瘤基因和瘤抑制基因,提供了新的癌症治疗方法. 像反意义核酸, ribozymes 和基因替代等技术对抑制癌症和增强免疫反应具有前途.

科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 基因治疗 基因治疗

背景情况:

  • 癌症包括瘤基因激活和瘤抑制基因失活.
  • 癌症中的遗传事件呈现出新的治疗点.
  • 基因转移为修改癌症治疗的体细胞提供了潜在的策略.

研究的目的:

  • 审查基因转移在癌症治疗中的潜在应用和伦理考虑.
  • 探索基因转移如何调节癌症患者的基因表达和细胞行为.

主要方法:

  • 审查当前的基因转移技术及其在瘤学中的应用.
  • 讨论用于基因表达调节的信息药物 (反意义核酸,核酶).
  • 探索遗传免疫调节和向前药物激活策略.

主要成果:

  • 基因转移可以通过调节瘤基因和瘤抑制基因表达来抑制恶性行为.
  • 基因免疫调节可以增强抗瘤免疫反应.
  • 有针对性的基因转移可以提高化疗的疗效,并保护正常组织.

结论:

  • 基因转移代表了癌症治疗的一个有希望的前沿,针对关键的遗传改变.

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  • 体细胞基因转移的伦理影响需要仔细考虑.
  • 未来的方向包括基因替代疗法,以恢复瘤抑制功能.