通过高剂量预防性OKT3诱导瘤在移植体内
D Abramowicz1, O Pradier, A Marchant
1Department of Nephrology, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Belgium.
Lancet (London, England)
|March 28, 1992
概括
移植患者的预防性OKT3导致9%的接受者发生移植内血栓. 这项研究证实了OKT3.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 血液学 血液学 血液学
背景情况:
- 移植是末期病的重要治疗方法.
- 预防性免疫抑制对于防止移植体排斥至关重要.
- OKT3 (muromonab-CD3) 是一种强大的免疫抑制抗体.
研究的目的:
- 在接受预防性OKT3.3的移植患者中调查移植内血栓的发生率和性质.
- 为了确定OKT3的给药是否与前凝效应有关.
主要方法:
- 对接受预防性OKT3 (10毫克/天2周) 的93名移植患者的回顾性分析.
- 在移植后2周内对移植内血栓的临床评估.
- 在第一个OKT3剂量后4小时测量血前热血素片段1和2水平.
主要成果:
- 在93名患者中,有9名患者 (9.7%) 在2周内发病了移植内血栓.
- 血栓事件包括移植动脉 (1),移植静脉 (3) 和血栓状毛细血管与血栓状微血管病 (5).
- 与对照组相比,在OKT3接受者中观察到血前列血片段1和2的升高水平,这表明了前凝剂活性.
结论:
- 预防性OKT3给药与移植受体体内移植血栓的显著风险有关.
- 在体内,OKT3表现出促凝血作用,导致血栓性并发症.
- 这些发现需要仔细考虑OKT3的使用和潜在的血栓形成风险管理策略.
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