在意大利东北部,初级胃淋巴瘤的发病率很高
C Doglioni1, A C Wotherspoon, A Moschini
1Ospedale Civile, Feltre, Italy.
Lancet (London, England)
|April 4, 1992
概括
初级胃淋巴瘤 (PGL) 发病率在意大利的费尔特雷是英国社区的13倍. 这项研究调查了PGL和胃癌的发病率,将它们与Helicobacter pylori感染的流行率联系起来.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 此前在意大利东北部观察到异常高的初级胃淋巴瘤 (PGL) 发病率.
- 胃癌和感染对全球健康构成重大挑战.
研究的目的:
- 为了正式比较意大利费尔特雷的PGL发病率与英国的类似社区.
- 在同一地区调查胃腺癌的发病率和Helicobacter pylori感染的流行率.
主要方法:
- 比较流行病学研究设计.比较流行病学研究设计.
- 分析了从1986年至1991年的PGL和胃腺癌发病率数据.
- 在1991年胃活检样本中评估Helicobacter pylori感染的流行率.
主要成果:
- 意大利的费尔特里 (Feltre) 的PGL病例比英国社区的13倍多 (66个相比5个每10万人5年).
- 费尔特的胃腺癌发病率明显高于费尔特的患者 (5年内每10万人中有270人,而每10万人中有82人).
- 与H. pylori感染相关的胃炎的患病率在Feltre高 (87%的样本).
结论:
- 初级胃淋巴瘤和胃腺癌的发病率在意大利费尔特雷显著增加.
- 高的Helicobacter pylori感染率可能会导致Feltre观察到的胃病理增加.
- 需要进一步的研究来阐明这些地理差异背后的病因因素.
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