启发氧度增加对慢性心力衰竭运动表现的影响
D P Moore1, A R Weston, J M Hughes
1Division of Clinical Cardiology, Royal Postgraduate Medical School, London, UK.
Lancet (London, England)
|April 4, 1992
概括
补充氧气可以改善心力衰竭患者的运动能力. 较高的氧气水平可以提高运动持续时间,减少呼吸困难和疲劳,这表明潜在的治疗益处.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 运动生理学 运动生理学
背景情况:
- 慢性心力衰竭 (CHF) 患者体验到有限的运动能力.
- 急性干预通常被认为对改善心血管疾病患者的运动耐受性是无效的.
研究的目的:
- 为了研究在稳定的心力衰竭患者中,在运动期间对心肺呼吸反应产生不同启发氧度的急性影响.
- 为了确定补充氧气是否可以急性改善运动表现,并修改CHF的生理反应.
主要方法:
- 12名患有慢性充血性心力衰竭的患者进行了连续的亚最大和最大运动测试.
- 测试是在21% (室内空气),30%和50%的吸入氧气度下进行的.
主要成果:
- 平均运动持续时间从室内空气下548s显著增加到50%氧气下632s (p=0.012).
- 在45W稳定状态运动中,50%的氧气增加了动脉氧和,减少了分钟通风,心脏输出,疲劳和喘息.
- 30%的氧气显示了中间作用.
结论:
- 增加的启发氧度可以急剧提高心力衰竭患者的运动表现.
- 过氧症改变了通风反应,减少了循环需求,同时保持了氧气供应.
- 在治疗慢性心力衰竭方面,高启发氧的潜力需要进一步研究.
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