针对氧化LDL和动脉动脉样硬化的进展的自身抗体
J T Salonen1, S Ylä-Herttuala, R Yamamoto
1Research Institute of Public Health, University of Kuopio, Finland.
Lancet (London, England)
|April 11, 1992
概括
对氧化LDL的自身抗体,特别是MDA修饰的LDL,与更快的动脉动脉样硬化进展有关. 这项研究发现,在患有加速动脉样硬化症的男性中,MDA-LDL抗体标位较高,这表明它在疾病发展中的作用.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 低密度脂蛋白 (LDL) 的氧化修饰会产生免疫原性表位.
- 针对氧化LDL表位体的自身抗体,如malondialdehyde (MDA) -lysine,存在于血清和动脉瘤组织中.
- 对氧化LDL在血管疾病进展中的重要性缺乏前性研究.
研究的目的:
- 调查氧化LDL的自身抗体标位与动脉动脉样硬化的进展之间的关联.
- 为了确定MDA修饰的LDL的自身抗体是否是动脉样硬化进展的独立预测因素.
主要方法:
- 在基线血清样本中,对MDA修饰的LDL和原生LDL的自身抗体标位的比较.
- 这项研究包括30名芬兰男性,他们的动脉样硬化进展加速,以及30名年龄相匹配的对照.
- 统计分析调整了吸烟,LDL胆固醇,血清铜,以及基线动脉样硬化的严重程度.
主要成果:
- 在这两组中都没有观察到与本地LDL结合的显著抗体.
- 加速动脉样硬化病例显示,MDA-LDL对MDA-LDL的自身抗体标位显著更高 (p = 0.003).
- 在多变量调整后,较高的MDA-LDL抗体标位仍然是动脉样硬化进展的独立预测因子 (p = 0.031).
结论:
- 对MDA修饰的LDL的自身抗体在患有渐进性动脉样硬化的人群中升高.
- 对MDA-LDL的自身抗体标位是芬兰男性动脉动脉样硬化进展的独立预测因子.
- 这些发现支持氧化修饰的LDL在动脉样硬化的发病过程中的作用.
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