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乙型肝炎病毒和明显的非A型,非B型 fulminant 肝炎
T L Wright1, D Mamish, C Combs
1Department of Veterans Affairs Medical Center, San Francisco, California 94121.
Lancet (London, England)
|April 18, 1992
概括
在非A,非B型肝炎患者的肝脏样本中检测到乙型肝炎病毒 (HBV) DNA,这表明HBV可能会导致 fulminant肝功能衰竭,即使没有血清学证据表明感染.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 移植 移植 移植 移植
背景情况:
- 发性肝衰竭 (FHF) 的病因通常不清楚,特别是在非A,非B型肝炎病例中.
- 型肝炎病毒 (HCV) 不被认为是FHF的原因,导致病因不明.
- 乙型肝炎病毒 (HBV) 感染是全球急性肝衰竭的重要原因之一.
研究的目的:
- 研究乙型肝炎病毒 (HBV) 在患有急性肝衰竭和非A,非B型肝炎的患者中的作用.
- 用敏感的分子技术在血清和肝脏样本中确定HBVDNA的存在.
- 评估血清标记与PCR在FHF中检测HBV的诊断效用.
主要方法:
- 从26名急性肝衰竭患者进行肝移植的血清和肝脏样本的未来采集.
- 两步聚合酶连锁反应 (PCR) 检测血清和肝脏组织中的HBVDNA.
- 评估了甲型肝炎病毒 (HAV) 和HBV血清标志物.
- 在移植前样本中使用PCR检测HCVRNA.
主要成果:
- 所有26名患者的移植前血清中没有HBVDNA.
- 在17名非A,非B型肝炎患者中,在6名 (35%) 的肝脏样本中检测到HBV DNA.
- 在患有HAV或毒素诱导的急性肝衰竭患者的肝样本中没有发现HBVDNA.
- 在任何移植前样本中没有检测到HCVRNA.
- 移植后血清HBVDNA在17名明显非A,非B型肝炎患者中的7名中检测到.
结论:
- 乙型肝炎病毒 (HBV) 是非A型,非B型肝炎的患者中 fulminant肝衰竭 (FHF) 的潜在常见原因.
- 标准血清测试可能会低估HBV在FHF中的作用.
- 敏感的PCR检测肝脏组织中的HBVDNA对于诊断未知病因的FHF至关重要.
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