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相关概念视频

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

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相关实验视频

Updated: Jun 29, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

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Published on: February 3, 2012

乙型肝炎病毒和明显的非A型,非B型 fulminant 肝炎.

T L Wright1, D Mamish, C Combs

  • 1Department of Veterans Affairs Medical Center, San Francisco, California 94121.

Lancet (London, England)
|April 18, 1992
PubMed
概括
此摘要是机器生成的。

在非A,非B型肝炎患者的肝脏样本中检测到乙型肝炎病毒 (HBV) DNA,这表明HBV可能会导致 fulminant肝功能衰竭,即使没有血清学证据表明感染.

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Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 病毒学 病毒学
  • 移植 移植 移植 移植

背景情况:

  • 发性肝衰竭 (FHF) 的病因通常不清楚,特别是在非A,非B型肝炎病例中.
  • 型肝炎病毒 (HCV) 不被认为是FHF的原因,导致病因不明.
  • 乙型肝炎病毒 (HBV) 感染是全球急性肝衰竭的重要原因之一.

研究的目的:

  • 研究乙型肝炎病毒 (HBV) 在患有急性肝衰竭和非A,非B型肝炎的患者中的作用.
  • 用敏感的分子技术在血清和肝脏样本中确定HBVDNA的存在.
  • 评估血清标记与PCR在FHF中检测HBV的诊断效用.

主要方法:

  • 从26名急性肝衰竭患者进行肝移植的血清和肝脏样本的未来采集.
  • 两步聚合酶连锁反应 (PCR) 检测血清和肝脏组织中的HBVDNA.
  • 评估了甲型肝炎病毒 (HAV) 和HBV血清标志物.
  • 在移植前样本中使用PCR检测HCVRNA.

主要成果:

  • 所有26名患者的移植前血清中没有HBVDNA.
  • 在17名非A,非B型肝炎患者中,在6名 (35%) 的肝脏样本中检测到HBV DNA.
  • 在患有HAV或毒素诱导的急性肝衰竭患者的肝样本中没有发现HBVDNA.
  • 在任何移植前样本中没有检测到HCVRNA.
  • 移植后血清HBVDNA在17名明显非A,非B型肝炎患者中的7名中检测到.

结论:

  • 乙型肝炎病毒 (HBV) 是非A型,非B型肝炎的患者中 fulminant肝衰竭 (FHF) 的潜在常见原因.
  • 标准血清测试可能会低估HBV在FHF中的作用.
  • 敏感的PCR检测肝脏组织中的HBVDNA对于诊断未知病因的FHF至关重要.