亚治愈化疗和致命的治疗后反应性脑病变在非洲试索米亚症中
C A Hunter1, F W Jennings, J H Adams
1Department of Veterinary Medicine, University of Glasgow, UK.
Lancet (London, England)
|April 18, 1992
概括
治疗非洲睡眠病的治疗方法可以导致危险的脑炎症. 通过积极的治疗来确保从中枢神经系统中消除寄生虫,可以防止这些治疗后反应.
科学领域:
- 神经科学是一个神经科学.
- 寄生虫学的寄生虫学
- 免疫学 免疫学 免疫学
背景情况:
- 晚期非洲睡眠病 (人类非洲试虫病) 的治疗因治疗后的反应性脑病变而复杂化.
- 这种反应背后的病理机制仍然不完全理解.
研究的目的:
- 为了研究治疗后反应性脑病变的基础,在非洲试索米病的小鼠模型中.
- 确定寄生虫在中枢神经系统 (CNS) 中的存在在触发这种反应中的作用.
主要方法:
- 使用了一种非洲试索米病的小鼠模型.
- 这些小鼠接受了治疗 (diminazene aceteturate) 或治疗 (melaminylthioarsenite和5-nitroimidazole) 的治疗.
- 评估了中枢神经系统中的寄生虫存在以及由此产生的病理反应. 用聚合酶链反应 (PCR) 在人类大脑样本中检测到三子体DNA.
主要成果:
- 治疗治疗,未能从中枢神经系统清除寄生虫,诱导脑膜炎类似于人类病例.
- 治愈治疗,消除中枢神经系统寄生虫,并没有引起小鼠的病理反应.
- 在9名因治疗后反应而死亡的人类患者的大脑中检测到三子体DNA.
结论:
- 治疗后的治疗,导致持续的中枢神经系统寄生虫,与治疗后脑病变的发展有关.
- 积极的治疗方案,确保从中枢神经系统完全消除寄生虫,可以防止这些患者的不良反应.
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