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皮肤恶性黑色素瘤,苏格兰,1979-89. 苏格兰黑色素瘤组织
R MacKie1, J A Hunter, T C Aitchison
1Department of Dermatology, Glasgow University, UK.
Lancet (London, England)
|April 18, 1992
概括
从1979年到1989年,苏格兰的黑色素瘤发病率显著增加,特别是表面扩散类型. 公共教育导致了更薄的黑色素瘤,改善了生存率,尤其是女性.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 苏格兰黑色素瘤小组 (SMG) 成立于1979年,用于监测苏格兰的皮肤恶性黑色素瘤 (CMM).
- 之前的报告涵盖了最初的发病率和存活率;这项研究分析了11年的数据.
研究的目的:
- 报告1979年至1989年苏格兰CMM发病率和死亡率的趋势.
- 检查这些趋势与解剖部位,病理类型和患者人口统计学有关.
- 评估公众教育对黑色素瘤发病率和存活率的影响.
主要方法:
- 分析了从1979年至1989年间被诊断患有初级CMM的1354名男性和2459名女性患者的数据.
- 计算每年每10万人口的发病率.
- 对1661名随访至少5年的患者的死亡率数据的审查.
主要成果:
- 从1979年到1989年,总体上CMM发病率增加了82% (每年7.4%).
- 在女性腿部和男性干部的表面传播黑色素瘤中,观察到的发生率增加最大.
- 在公共教育 (1985年起) 之后,发现黑色素瘤<1.5毫米厚度的显著增加.
- 五年生存率总体为71.6% (女性为77.6%,男性为58.7%),女性表现出持续的生存优势.
结论:
- 苏格兰的CMM发病率明显增加,特定的亚型和位置显示增长最快.
- 公共卫生倡议似乎有效地促进早期检测较薄的黑色素瘤.
- 在调整预后因素后,黑色素瘤存活率的性别差异仍然存在,突出了针对性预防和管理策略的需要.
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