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Updated: Jun 24, 2026

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
10:59

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

增殖细胞核抗原是DNA切割修复所需的

K K Shivji1, M K Kenny, R D Wood

  • 1Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, England.

Cell
|April 17, 1992
PubMed
概括

研究人员确定了参与DNA修复的关键蛋白质,特别是XP-A蛋白和人类单链DNA结合蛋白 (HSSB),它们对于切割受损DNA至关重要. 增殖细胞核抗原 (PCNA) 在这个修复途径中对随后的DNA合成阶段至关重要.

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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