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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Rh Blood Group01:19

Rh Blood Group

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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
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相关实验视频

Updated: Jul 12, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

通过母体单细胞反应性IgG配抗体 (抗HLA-DR) 保护新生儿免受免疫血液溶解性疾病.

M C Dooren1, R W Kuijpers, E C Joekes

  • 1Department of Immunohaematology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.

Lancet (London, England)
|May 2, 1992
PubMed
概括

对父亲单细胞抗原的母体IgG配抗体可以保护Rh (D) 阳性婴儿免受新生儿严重溶血性疾病 (HDN) 的侵害. 这些抗体阻断抗体依赖的细胞中介细胞毒性 (ADCC),减轻胎儿血液溶解.

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Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis
10:13

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis

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相关实验视频

Last Updated: Jul 12, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

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Published on: May 21, 2015

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis
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Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis

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科学领域:

  • 免疫学 免疫学 免疫学
  • 周围生理学 周围生理学
  • 遗传学 是一个遗传学.

背景情况:

  • 母亲的抗RhD抗体与新生儿的RhD血液溶解性疾病 (HDN) 严重程度通过抗体依赖的细胞介导细胞毒性 (ADCC) 相相关.
  • 一些婴儿表现出比ADCC值预测的轻度HDN,这表明有保护机制.
  • 研究了对父单细胞抗原的母性艾洛抗体在调节胎儿HDN严重性的作用.

研究的目的:

  • 调查假设,母体ADCC阻断性对父单细胞抗原的抗体可以保护婴儿免受严重的Rh(D) 溶血性疾病的影响.
  • 为了比较婴儿母亲的抗体概况,婴儿有意想不到的轻度HDN与那些严重的HDN.

主要方法:

  • 研究了13名患有严重Rh(D) 异免疫妊娠和意外轻度婴儿HDN (I组) 的母亲.
  • 与14名具有类似ADCC值但严重婴儿HDN (II组) 的母亲相比.
  • 在ADCC中测试了抑制单细胞溶解的单细胞反应性IgG配抗体,包括HLA-DR特异性.

主要成果:

  • 在I组的母亲中,有7名 (54%) 具有抑制ADCC的单细胞反应性IgG配抗体,而在II组没有 (p <0.01).
  • 在这7种抗体中,有6种表现出HLA-DR特异性.
  • 这些发现表明,保护性配方抗体和较温和的HDN结局之间存在显著的关联.

结论:

  • 对父亲单细胞抗原的母体非HLA-class-I IgG配抗体可以保护Rh(D) 阳性婴儿免受严重的HDN.
  • 这些抗体可能会抑制胎儿单核细胞系统,减少血液溶解.
  • 这一发现为管理Rh(D) 免疫接种和预防严重的HDN提供了潜在的见解.